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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50357898
Substrate
n/a
Meas. Tech.
ChEMBL_787640 (CHEMBL1918093)
IC50
77±n/a nM
Citation
 Lumeras, W; Vidal, L; Vidal, B; Balagué, C; Orellana, A; Maldonado, M; Domínguez, M; Segarra, V; Caturla, F 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem 54:7899-910 (2011) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50357898
Synonyms:
CHEMBL1916355
Type:
Small organic molecule
Emp. Form.:
C21H14F2N2O2
Mol. Mass.:
364.3449
SMILES:
COc1ccccc1-c1ccnc2c(-c3c(F)cccc3F)[n+]([O-])ccc12 |(15.24,2.65,;16.58,1.89,;17.91,2.66,;17.9,4.2,;19.24,4.97,;20.58,4.2,;20.58,2.66,;19.24,1.89,;19.24,.36,;20.58,-.42,;20.58,-1.96,;19.23,-2.73,;17.9,-1.96,;16.57,-2.74,;16.58,-4.27,;15.24,-5.04,;13.91,-4.27,;15.25,-6.58,;16.58,-7.35,;17.92,-6.57,;17.91,-5.03,;19.24,-4.25,;15.24,-1.96,;13.91,-2.73,;15.24,-.42,;16.57,.35,;17.91,-.41,)|
Structure:
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