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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50357901
Substrate
n/a
Meas. Tech.
ChEMBL_787640 (CHEMBL1918093)
IC50
37±n/a nM
Citation
 Lumeras, W; Vidal, L; Vidal, B; Balagué, C; Orellana, A; Maldonado, M; Domínguez, M; Segarra, V; Caturla, F 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem 54:7899-910 (2011) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50357901
Synonyms:
CHEMBL1916358
Type:
Small organic molecule
Emp. Form.:
C20H11Cl3N2O
Mol. Mass.:
401.673
SMILES:
[O-][n+]1ccc2c(ccnc2c1-c1c(Cl)cccc1Cl)-c1ccccc1Cl |(1.89,-22.15,;3.22,-21.39,;3.23,-19.84,;4.55,-19.07,;5.89,-19.83,;7.22,-19.06,;8.56,-19.84,;8.56,-21.38,;7.22,-22.15,;5.89,-21.38,;4.56,-22.16,;4.56,-23.69,;3.23,-24.46,;1.89,-23.69,;3.23,-26,;4.57,-26.77,;5.9,-25.99,;5.89,-24.45,;7.22,-23.67,;7.22,-17.53,;8.56,-16.76,;8.56,-15.22,;7.23,-14.45,;5.89,-15.23,;5.89,-16.76,;4.56,-17.54,)|
Structure:
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