Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM50362348
Substrate
n/a
Meas. Tech.
ChEMBL_797692 (CHEMBL1943912)
IC50
1.32±n/a nM
Citation
 Qian, W; Chen, JJ; Human, J; Aya, T; Zhu, J; Biswas, K; Peterkin, T; Hungate, RW; Arik, L; Johnson, E; Kumar, G; Joseph, S; Jona, J; Guo, HX; Wu, Z Discovery of dehydro-oxopiperazine acetamides as novel bradykinin B1 receptor antagonists with enhanced in vitro potency. Bioorg Med Chem Lett 22:1061-7 (2012) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50362348
Synonyms:
CHEMBL1939921
Type:
Small organic molecule
Emp. Form.:
C22H23N3O6S2
Mol. Mass.:
489.565
SMILES:
Cc1ccc(cc1)S(=O)(=O)N1C=CNC(=O)[C@H]1CC(=O)N[C@@H]1CCS(=O)(=O)c2ccccc12 |r,c:12|
Structure:
Search PDB for entries with ligand similarity: