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Target
Neutrophil collagenase
Ligand
BDBM50363128
Substrate
n/a
Meas. Tech.
ChEMBL_800774 (CHEMBL1948221)
IC50
15±n/a nM
Citation
 Schrigten, D; Breyholz, HJ; Wagner, S; Hermann, S; Schober, O; Schäfers, M; Haufe, G; Kopka, K A new generation of radiofluorinated pyrimidine-2,4,6-triones as MMP-targeted radiotracers for positron emission tomography. J Med Chem 55:223-32 (2012) [PubMed]  Article 
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50363128
Synonyms:
CHEMBL1946276
Type:
Small organic molecule
Emp. Form.:
C38H45FN8O9S
Mol. Mass.:
808.876
SMILES:
CN(Cc1cn(CCOCCOCCOCCN2CCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)nn1)S(=O)(=O)c1ccc(F)cc1
Structure:
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