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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50363444
Substrate
n/a
Meas. Tech.
ChEMBL_800180 (CHEMBL1947742)
EC50
42±n/a nM
Citation
 Furukawa, A; Arita, T; Fukuzaki, T; Satoh, S; Mori, M; Honda, T; Matsui, Y; Wakabayashi, K; Hayashi, S; Araki, K; Ohsumi, J Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPAR¿ partial agonists. Bioorg Med Chem Lett 22:1348-51 (2012) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50363444
Synonyms:
CHEMBL1945220
Type:
Small organic molecule
Emp. Form.:
C33H31NO9
Mol. Mass.:
585.6005
SMILES:
COC(=O)CCCc1cc(CNC(=O)c2c3OC4=CC(=O)C(C(C)=O)C(=O)[C@@]4(C)c3c(O)cc2OC)c2ccccc2c1 |r,t:17|
Structure:
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