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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50364394
Substrate
n/a
Meas. Tech.
ChEMBL_805217 (CHEMBL1955695)
IC50
20000±n/a nM
Citation
 Wu, Z; Yang, C; Xiong, Y; Feng, Z; Lombardo, M; Verras, A; Chabin, RM; Xu, S; Tong, X; Xie, D; Lassman, ME; Bhatt, UR; Garcia-Calvo, MM; Geissler, W; Shen, Z; Chen, Q; Sinharoy, R; Hale, JJ; Tata, JR; Pinto, S; Shen, DM; Colletti, SL Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine. Bioorg Med Chem Lett 22:1774-8 (2012) [PubMed]  Article 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase
Type:
PROTEIN
Mol. Mass.:
55028.96
Organism:
Mus musculus
Description:
ChEMBL_1335505
Residue:
491
Sequence:
MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGFADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWNVIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLPAWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNIIFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMKKWILDFYSNIQ
  
Inhibitor
Name:
BDBM50364394
Synonyms:
CHEMBL1950310
Type:
Small organic molecule
Emp. Form.:
C22H24Cl2FN5O
Mol. Mass.:
464.363
SMILES:
C[C@H](NC(=O)CCN1CCN(CC1)c1ccc(F)cc1)c1nc2cc(Cl)c(Cl)cc2[nH]1 |r|
Structure:
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