Reaction Details Report a problem with these data
Target
Platelet-activating factor receptor
Ligand
BDBM50280480
Substrate
n/a
Meas. Tech.
ChEBML_155000
IC50
2.3±n/a nM
Citation
 Hodgkin, EE; Miller, A; Whittaker, M A partial pharmacophore for the platelet activating factor (PAF) receptor Bioorg Med Chem Lett 2:597-602 (1992)    Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM50280480
Synonyms:
CHEMBL156461 | YM-461 | [4-(3-Phenyl-propyl)-piperazin-1-yl]-((R)-2-pyridin-3-yl-thiazolidin-4-yl)-methanone
Type:
Small organic molecule
Emp. Form.:
C22H28N4OS
Mol. Mass.:
396.549
SMILES:
O=C([C@@H]1CSC(N1)c1cccnc1)N1CCN(CCCc2ccccc2)CC1
Structure:
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