Reaction Details Report a problem with these data
Target
Neprilysin
Ligand
BDBM50282845
Substrate
n/a
Meas. Tech.
ChEBML_144599
IC50
2.6±n/a nM
Citation
Delaney, NG; Barrish, JC; Neubeck, R; Natarajan, S; Cohen, M; Rovnyak, GC; Huber, G; Murugesan, N; Girotra, R; Sieber-McMaster, E; Robl, JA; Asaad, MM; Cheung, HS; Bird, J; Waldron, T; Petrillo, EW Mercaptoacyl dipeptides as dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase. Preliminary structure-activity studies Bioorg Med Chem Lett 4:1783-1788 (1994) Article
More Info.:
Target
Name:
Neprilysin
Synonyms:
Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11
Type:
Protein
Mol. Mass.:
85789.59
Organism:
Rat
Description:
P07861
Residue:
750
Sequence:
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW
Inhibitor
Name:
BDBM50282845
Synonyms:
(S)-1-[(S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-propionyl]-2,3-dihydro-1H-indole-2-carboxylic acid | CHEMBL50582
Type:
Small organic molecule
Emp. Form.:
C22H24N2O4S
Mol. Mass.:
412.502
SMILES:
C[C@H](NC(=O)[C@@H](CS)Cc1ccccc1)C(=O)N1[C@@H](Cc2ccccc12)C(O)=O