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Target
Endothelin receptor type B
Ligand
BDBM50070878
Substrate
n/a
Meas. Tech.
ChEBML_63877
IC50
1200±n/a nM
Citation
 Mederski, WW; Dorsch, D; Osswald, M; Anzali, S; Christadler, M; Schmitges, CJ; Schelling, P; Wilm, C; Fluck, M Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist. Bioorg Med Chem Lett 8:1771-6 (1999) [PubMed]  Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_PIG | Endothelin receptor ET-B
Type:
PROTEIN
Mol. Mass.:
49616.89
Organism:
Sus scrofa
Description:
ChEMBL_63872
Residue:
443
Sequence:
MQPLRSLCGRALVALIFACGVAGVQSEERGFPPAGATPPALRTGEIVAPPTKTFWPRGSNASLPRSSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEALGFDMITTDYKGNRLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQNDSNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50070878
Synonyms:
CHEMBL48881 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol-5-yl-3-benzyl-4-(4-methoxy-phenyl)-4-oxo-but-2-enoate
Type:
Small organic molecule
Emp. Form.:
C24H17N2O4S
Mol. Mass.:
429.468
SMILES:
COc1ccc(cc1)C(=O)C(\Cc1ccccc1)=C(/C([O-])=O)c1ccc2nsnc2c1
Structure:
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