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Target
Tissue alpha-L-fucosidase
Ligand
BDBM50118927
Substrate
n/a
Meas. Tech.
ChEMBL_33949 (CHEMBL649574)
IC50
7600±n/a nM
Citation
 Ogawa, S; Mori, M; Takeuchi, G; Doi, F; Watanabe, M; Sakata, Y Convenient synthesis and evaluation of enzyme inhibitory activity of several N-alkyl-, N-phenylalkyl, and cyclic isourea derivatives of 5a-carba-alpha-DL-fucopyranosylamine. Bioorg Med Chem Lett 12:2811-4 (2002) [PubMed]  Article 
Target
Name:
Tissue alpha-L-fucosidase
Synonyms:
Alpha-L-fucosidase I | Alpha-L-fucoside fucohydrolase | FUCA1 | FUCO_HUMAN | Tissue alpha-L-fucosidase
Type:
PROTEIN
Mol. Mass.:
53690.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_34088
Residue:
466
Sequence:
MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
  
Inhibitor
Name:
BDBM50118927
Synonyms:
(6R,7S,7aS)-5-Methyl-2-phenylamino-3a,4,5,6,7,7a-hexahydro-benzooxazole-6,7-diol | CHEMBL94486
Type:
Small organic molecule
Emp. Form.:
C14H18N2O3
Mol. Mass.:
262.3043
SMILES:
CC1CC2N=C(Nc3ccccc3)OC2C(O)C1O |t:4|
Structure:
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