Reaction Details Report a problem with these data
Target
Neutrophil collagenase
Ligand
BDBM50148208
Substrate
n/a
Meas. Tech.
ChEMBL_105211 (CHEMBL713850)
IC50
0.4±n/a nM
Citation
Reiter, LA; Robinson, RP; McClure, KF; Jones, CS; Reese, MR; Mitchell, PG; Otterness, IG; Bliven, ML; Liras, J; Cortina, SR; Donahue, KM; Eskra, JD; Griffiths, RJ; Lame, ME; Lopez-Anaya, A; Martinelli, GJ; McGahee, SM; Yocum, SA; Lopresti-Morrow, LL; Tobiassen, LM; Vaughn-Bowser, ML Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett 14:3389-95 (2004) [PubMed] Article
More Info.:
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
Inhibitor
Name:
BDBM50148208
Synonyms:
3-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-8-oxa-bicyclo[3.2.1]octane-3-carboxylic acid hydroxyamide | CHEMBL321633
Type:
Small organic molecule
Emp. Form.:
C20H21FN2O6S
Mol. Mass.:
436.454
SMILES:
ONC(=O)C1(CC2CCC(C1)O2)NS(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1