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Target
Beta-lactamase
Ligand
BDBM50142711
Substrate
n/a
Meas. Tech.
ChEBML_41188
Ki
29000±n/a nM
Citation
 Tsang, WY; Dhanda, A; Schofield, CJ; Frère, JM; Galleni, M; Page, MI The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives. Bioorg Med Chem Lett 14:1737-9 (2004) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_ENTCL | ampC
Type:
PROTEIN
Mol. Mass.:
41306.67
Organism:
Enterobacter cloacae
Description:
ChEMBL_40258
Residue:
381
Sequence:
MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTITPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDAVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ
  
Inhibitor
Name:
BDBM50142711
Synonyms:
(R)-5-Methyl-2-(6-oxo-5-phenyl-3-thioxo-piperazin-2-yl)-3,6-dihydro-2H-[1,3]thiazine-4-carboxylic acid anion
Type:
Small organic molecule
Emp. Form.:
C16H16N3O3S2
Mol. Mass.:
362.447
SMILES:
CC1CS[C@@H](NC1C([O-])=O)c1nc(O)c([nH]c1=S)-c1ccccc1
Structure:
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