Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50024821
Substrate
n/a
Meas. Tech.
ChEBML_152596
Ki
51100±n/a nM
Citation
 Grunewald, GL; Markovich, KM; Sall, DJ Binding orientation of amphetamine and norfenfluramine analogues in the benzonorbornene and benzobicyclo[3.2.1]octane ring systems at the active site of phenylethanolamine N-methyltransferase (PNMT) J Med Chem 30:2191-208 (1988) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50024821
Synonyms:
4-Trifluoromethyl-6,7,8,9-tetrahydro-5H-5,8-methano-benzocyclohepten-10-ylamine | CHEMBL71964
Type:
Small organic molecule
Emp. Form.:
C13H14F3N
Mol. Mass.:
241.2522
SMILES:
N[C@@H]1C2CCC1c1c(C2)cccc1C(F)(F)F |TLB:12:6:1:4.3,0:1:6.7.8:4.3,THB:9:7:1:4.3|
Structure:
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