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Target
Kappa-type opioid receptor
Ligand
BDBM50045116
Substrate
n/a
Meas. Tech.
ChEMBL_146376 (CHEMBL754733)
Ki
2622±n/a nM
Citation
 Ronsisvalle, G; Pasquinucci, L; Pappalardo, MS; Vittorio, F; Fronza, G; Romagnoli, C; Pistacchio, E; Spampinato, S; Ferri, S Non-peptide ligands for opioid receptors. Design of kappa-specific agonists. J Med Chem 36:1860-5 (1993) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Guinea pig
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50045116
Synonyms:
2-(8-Hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-ylmethyl)-1-phenyl-cyclopropanecarboxylic acid methyl ester | CHEMBL52307
Type:
Small organic molecule
Emp. Form.:
C26H31NO3
Mol. Mass.:
405.5292
SMILES:
COC(=O)[C@@]1(C[C@@H]1CN1CC[C@]2(C)[C@@H](C)[C@H]1Cc1ccc(O)cc21)c1ccccc1 |TLB:7:8:13:23.17.16|
Structure:
Search PDB for entries with ligand similarity: