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Target
Carbonic anhydrase 2
Ligand
BDBM50031454
Substrate
n/a
Meas. Tech.
ChEMBL_45052 (CHEMBL658050)
Kd
43±n/a nM
Citation
 Boriack, PA; Christianson, DW; Kingery-Wood, J; Whitesides, GM Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants. J Med Chem 38:2286-91 (1995) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Human
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50031454
Synonyms:
(2-{2-[2-(4-Sulfamoyl-benzoylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-methyl-ammonium
Type:
Small organic molecule
Emp. Form.:
C15H25N4O6S
Mol. Mass.:
389.447
SMILES:
NS(=O)(=O)c1ccc(cc1)C(=O)NCCOCCOCCNC(=O)C[NH3+]
Structure:
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