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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50083306
Substrate
n/a
Meas. Tech.
ChEMBL_1432 (CHEMBL616306)
Ki
11±n/a nM
Citation
 Abou-Gharbia, MA; Childers, WE; Fletcher, H; McGaughey, G; Patel, U; Webb, MB; Yardley, J; Andree, T; Boast, C; Kucharik, RJ; Marquis, K; Morris, H; Scerni, R; Moyer, JA Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. J Med Chem 42:5077-94 (2000) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50083306
Synonyms:
CHEMBL553024 | N-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-2-(3-methyl-adamantan-1-yl)-acetamide; Dihydrochloride
Type:
Small organic molecule
Emp. Form.:
C26H39N3O2
Mol. Mass.:
425.6068
SMILES:
COc1ccccc1N1CCN(CCNC(=O)CC23C[C@H]4C[C@H](C[C@](C)(C4)C2)C3)CC1 |TLB:25:24:19:22.28.21,THB:23:24:19:22.28.21,23:22:19:24.27.26|
Structure:
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