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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50074600
Substrate
n/a
Meas. Tech.
ChEMBL_62303 (CHEMBL675225)
IC50
14.2±n/a nM
Citation
 Deutsch, HM; Collard, DM; Zhang, L; Burnham, KS; Deshpande, AK; Holtzman, SG; Schweri, MM Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-(aminomethyl)-3-phenylbicyclo[2.2.2]- and -[2.2.1]alkane dopamine uptake inhibitors. J Med Chem 42:882-95 (1999) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50074600
Synonyms:
CHEMBL358368 | [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmethyl]-dimethyl-amine
Type:
Small organic molecule
Emp. Form.:
C17H23Cl2N
Mol. Mass.:
312.277
SMILES:
CN(C)CC1C2CCC(CC2)C1c1ccc(Cl)c(Cl)c1 |TLB:12:11:6.7:10.9,3:4:6.7:10.9,(14.29,-10.51,;12.82,-10.91,;12.42,-12.4,;11.72,-9.83,;10.24,-10.23,;8.64,-9.3,;8.64,-7.92,;9.48,-7.09,;9.48,-8.18,;7.78,-8.95,;7.01,-10.17,;11.05,-9.11,;11.79,-7.76,;11.02,-6.45,;11.76,-5.1,;13.32,-5.1,;14.1,-3.67,;14.09,-6.42,;15.64,-6.42,;13.33,-7.76,)|
Structure:
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