Reaction Details Report a problem with these data
Target
P2X purinoceptor 1
Ligand
BDBM50118218
Substrate
n/a
Meas. Tech.
ChEMBL_149733 (CHEMBL759516)
IC50
8800±n/a nM
Citation
 Jacobson, KA; Jarvis, MF; Williams, M Purine and pyrimidine (P2) receptors as drug targets. J Med Chem 45:4057-93 (2002) [PubMed]  Article 
Target
Name:
P2X purinoceptor 1
Synonyms:
ATP receptor | P2RX1_RAT | P2X1 | P2rx1 | Purinergic receptor | Purinergic, P2X1 | RP-2 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44969.95
Organism:
RAT
Description:
Purinergic, P2X1 0 RAT::P47824
Residue:
399
Sequence:
MARRLQDELSAFFFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFVYEKGYQTSSDLISSVSVKLKGLAVTQLQGLGPQVWDVADYVFPAHGDSSFVVMTNFIVTPQQTQGHCAENPEGGICQDDSGCTPGKAERKAQGIRTGNCVPFNGTVKTCEIFGWCPVEVDDKIPSPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNGTYMKKCLYHKIQHPLCPVFNLGYVVRESGQDFRSLAEKGGVVGITIDWKCDLDWHVRHCKPIYQFHGLYGEKNLSPGFNFRFARHFVQNGTNRRHLFKVFGIHFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGEGEHDPVATSSTLGLQENMRTS
  
Inhibitor
Name:
BDBM50118218
Synonyms:
CHEMBL131271 | Disodium 1-amino-4-[4-(4,6-dichloro-[1,3,5]triazine-2-ylamino)-3-sulfophenylamino]-9,10-dioxo-9,10-di-hydroanthracene-2-sulfonate | MG 40-1
Type:
Small organic molecule
Emp. Form.:
C23H12Cl2N6O8S2
Mol. Mass.:
635.414
SMILES:
Nc1c(cc(Nc2ccc(Nc3nc(Cl)nc(Cl)n3)c(c2)S([O-])(=O)=O)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Structure:
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