Reaction Details
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Report a problem with these dataTarget
Growth hormone secretagogue receptor type 1
Ligand
BDBM50370294
Substrate
n/a
Meas. Tech.
ChEMBL_72506 (CHEMBL685171)
IC50
18±n/a nM
Citation
Guerlavais, V; Boeglin, D; Mousseaux, D; Oiry, C; Heitz, A; Deghenghi, R; Locatelli, V; Torsello, A; Ghé, C; Catapano, F; Muccioli, G; Galleyrand, JC; Fehrentz, JA; Martinez, J New active series of growth hormone secretagogues. J Med Chem 46:1191-203 (2003) [PubMed] Article More Info.:
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Human
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
Inhibitor
Name:
BDBM50370294
Synonyms:
Examorelin | HEXARELIN | US9708370, Hexareline
Type:
Small organic molecule
Emp. Form.:
C47H58N12O6
Mol. Mass.:
887.0402
SMILES:
C[C@H](NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O
Structure:
