Reaction Details Report a problem with these data
Target
Transporter
Ligand
BDBM50138638
Substrate
n/a
Meas. Tech.
ChEMBL_143112 (CHEMBL749361)
Ki
454±n/a nM
Citation
 Carroll, FI; Pawlush, N; Kuhar, MJ; Pollard, GT; Howard, JL Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes. J Med Chem 47:296-302 (2004) [PubMed]  Article 
Target
Name:
Transporter
Synonyms:
Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters
Type:
PROTEIN
Mol. Mass.:
66787.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1463061
Residue:
597
Sequence:
MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI
  
Inhibitor
Name:
BDBM50138638
Synonyms:
3-(4-Chloro-phenyl)-2-[3-(4-methoxy-phenyl)-isoxazol-5-yl]-8-methyl-8-aza-bicyclo[3.2.1]octane | CHEMBL320627
Type:
Small organic molecule
Emp. Form.:
C24H25ClN2O2
Mol. Mass.:
408.921
SMILES:
COc1ccc(cc1)-c1cc(on1)C1C2CCC(CC1c1ccc(Cl)cc1)N2C |THB:10:13:27:15.16,20:19:27:15.16|
Structure:
Search PDB for entries with ligand similarity: