Reaction Details
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Guanine nucleotide-binding protein G(i) subunit alpha-3
Ligand
BDBM50174642
Substrate
n/a
Meas. Tech.
ChEMBL_321105 (CHEMBL882871)
EC50
6100±n/a nM
Citation
Manetti, D; Di Cesare Mannelli, L; Dei, S; Galeotti, N; Ghelardini, C; Romanelli, MN; Scapecchi, S; Teodori, E; Pacini, A; Bartolini, A; Gualtieri, F Design, synthesis, and preliminary pharmacological evaluation of a set of small molecules that directly activate gi proteins. J Med Chem 48:6491-503 (2005) [PubMed] Article More Info.:
Target
Name:
Guanine nucleotide-binding protein G(i) subunit alpha-3
Synonyms:
GNAI3 | GNAI3_HUMAN | Guanine nucleotide-binding protein G(k), alpha-3 subunit
Type:
PROTEIN
Mol. Mass.:
40527.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_321105
Residue:
354
Sequence:
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAEEGVMTPELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQSNYIPTQQDVLRTRVKTTGIVETHFTFKDLYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY
Inhibitor
Name:
BDBM50174642
Synonyms:
1-{4-[2-(1-Methyl-piperidin-4-yl)-ethyl]-piperidin-1-yl}-pentadecan-1-one; hydrochloride | CHEMBL536732
Type:
Small organic molecule
Emp. Form.:
C28H54N2O
Mol. Mass.:
434.7412
SMILES:
CCCCCCCCCCCCCCC(=O)N1CCC(CCC2CCN(C)CC2)CC1
Structure:
