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Target
Kappa-type opioid receptor
Ligand
BDBM50199896
Substrate
n/a
Meas. Tech.
ChEMBL_422438 (CHEMBL909313)
Ki
9±n/a nM
Citation
Le Bourdonnec, B; Goodman, AJ; Michaut, M; Ye, HF; Graczyk, TM; Belanger, S; Herbertz, T; Yap, GP; DeHaven, RN; Dolle, RE Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists. J Med Chem 49:7278-89 (2006) [PubMed] Article
More Info.:
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Human
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
Inhibitor
Name:
BDBM50199896
Synonyms:
3-((2R,3R,7S,9-alpha-S)-2,3-dimethyl-7-phenyl-octahydro-1H-quinolizin-2-yl)phenol | 3-((2R,3R,7S,9aS)-2,3-dimethyl-7-phenyl-octahydro-1H-quinolizin-2-yl)phenol | CHEMBL426523 | US8580788, 56
Type:
Small organic molecule
Emp. Form.:
C23H29NO
Mol. Mass.:
335.4825
SMILES:
C[C@H]1CN2C[C@@H](CC[C@H]2C[C@@]1(C)c1cccc(O)c1)c1ccccc1 |r|