Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50210184
Substrate
n/a
Meas. Tech.
ChEMBL_443954 (CHEMBL893121)
Ki
29.5±n/a nM
Citation
 Weigl, M; Wünsch, B Synthesis of bridged piperazines with sigma receptor affinity. Eur J Med Chem 42:1247-62 (2007) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50210184
Synonyms:
(1R,2R,5S )-6-benzyl-8-(2-phenylethyl)-6,8-diazabicyclo[3.2.2]nonan-2-ol | CHEMBL242077
Type:
Small organic molecule
Emp. Form.:
C22H28N2O
Mol. Mass.:
336.4705
SMILES:
O[C@H]1CCC2CN(CCc3ccccc3)C1CN2Cc1ccccc1 |w:15.17,4.3,TLB:0:1:17.16:5.6,18:17:3.2.1:5.6,7:6:17.16:3.2.1|
Structure:
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