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Target
Nuclear receptor subfamily 4 group A member 2
Ligand
BDBM50196291
Substrate
n/a
Meas. Tech.
ChEMBL_453027 (CHEMBL902174)
EC50
0.8±n/a nM
Citation
 Hintermann, S; Chiesi, M; von Krosigk, U; Mathé, D; Felber, R; Hengerer, B Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg Med Chem Lett 17:193-6 (2006) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 4 group A member 2
Synonyms:
NOT | NR4A2 | NR4A2_HUMAN | NURR1 | TINUR
Type:
PROTEIN
Mol. Mass.:
66603.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_453027
Residue:
598
Sequence:
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
  
Inhibitor
Name:
BDBM50196291
Synonyms:
6-(benzo[d][1,3]dioxol-5-yl)-5-methyl-3-phenylisoxazolo[4,5-c]pyridin-4(5H)-one | CHEMBL399603
Type:
Small organic molecule
Emp. Form.:
C20H14N2O4
Mol. Mass.:
346.3362
SMILES:
Cn1c(cc2onc(-c3ccccc3)c2c1=O)-c1ccc2OCOc2c1
Structure:
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