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Target
Delta-type opioid receptor
Ligand
BDBM50375379
Substrate
n/a
Meas. Tech.
ChEMBL_471596 (CHEMBL940227)
Ki
740±n/a nM
Citation
 Jung, B; Englberger, W; Fröhlich, R; Schepmann, D; Lehmkuhl, K; Wünsch, B Synthesis and pharmacological evaluation of bicyclic SNC80 analogues with separated benzhydryl moiety. Bioorg Med Chem 16:2870-85 (2008) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50375379
Synonyms:
CHEMBL260519
Type:
Small organic molecule
Emp. Form.:
C28H35N3O
Mol. Mass.:
429.597
SMILES:
CCN(CC)C(=O)c1ccc(CN2C[C@H]3CC=C([C@@H]2CN3CC=C)c2ccccc2)cc1 |wU:18.18,wD:14.21,c:16,TLB:24:17:20.19:13.12,11:12:20.19:15.16.17,THB:21:20:13.12:15.16.17,(-7.97,-38.58,;-6.63,-37.81,;-5.3,-38.58,;-5.3,-40.12,;-6.63,-40.89,;-3.97,-37.82,;-3.97,-36.27,;-2.64,-38.58,;-2.64,-40.13,;-1.31,-40.9,;.02,-40.13,;1.36,-40.9,;2.73,-40.2,;3.78,-39.02,;5.37,-39.07,;6.35,-40.4,;5.89,-41.97,;5.32,-40.73,;4.02,-40.08,;4.86,-38.45,;6.06,-37.71,;7.1,-36.59,;8.61,-36.92,;9.65,-35.8,;4.23,-41.83,;2.73,-41.37,;1.65,-42.46,;2,-43.94,;3.49,-44.38,;4.58,-43.3,;.02,-38.58,;-1.31,-37.82,)|
Structure:
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