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Target
Equilibrative nucleoside transporter 1
Ligand
BDBM50411990
Substrate
n/a
Meas. Tech.
ChEMBL_478938 (CHEMBL936364)
IC50
181.97±n/a nM
Citation
 Zhu, Z; Buolamwini, JK Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity. Bioorg Med Chem 16:3848-65 (2008) [PubMed]  Article 
Target
Name:
Equilibrative nucleoside transporter 1
Synonyms:
ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1
Type:
Multi-pass membrane protein
Mol. Mass.:
50225.92
Organism:
Human
Description:
n/a
Residue:
456
Sequence:
MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAILLVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKLEGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
  
Inhibitor
Name:
BDBM50411990
Synonyms:
CHEMBL261793
Type:
Small organic molecule
Emp. Form.:
C19H22N6O5
Mol. Mass.:
414.4152
SMILES:
CC(=O)Nc1ccc(CNc2ncnc3n(cnc23)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1
Structure:
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