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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50251921
Substrate
n/a
Meas. Tech.
ChEMBL_488009 (CHEMBL1013888)
IC50
11±n/a nM
Citation
 Laufer, SA; Hauser, DR; Domeyer, DM; Kinkel, K; Liedtke, AJ Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region. J Med Chem 51:4122-49 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50251921
Synonyms:
CHEMBL481749 | trans-4-{4-[2-Methylsulfanyl-4-(3-trifluoromethyl-phenyl)-1H-imidazol-5-yl]-pyridin-2-ylamino}-cyclohexanol
Type:
Small organic molecule
Emp. Form.:
C22H23F3N4OS
Mol. Mass.:
448.504
SMILES:
CSc1nc(c([nH]1)-c1cccc(c1)C(F)(F)F)-c1ccnc(N[C@H]2CC[C@H](O)CC2)c1 |r,wU:26.28,wD:23.24,(26.57,-40.06,;25.8,-38.72,;24.26,-38.72,;23.35,-39.96,;21.89,-39.48,;21.89,-37.94,;23.36,-37.47,;20.57,-37.16,;19.23,-37.92,;17.91,-37.15,;17.91,-35.6,;19.25,-34.84,;20.58,-35.62,;19.26,-33.3,;19.25,-31.76,;20.8,-33.3,;17.72,-33.31,;20.56,-40.24,;19.22,-39.47,;17.89,-40.24,;17.89,-41.78,;19.23,-42.55,;19.24,-44.09,;20.58,-44.86,;20.57,-46.4,;21.9,-47.16,;23.24,-46.39,;24.57,-47.16,;23.24,-44.85,;21.9,-44.08,;20.56,-41.78,)|
Structure:
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