Reaction Details Report a problem with these data
Target
Beta-2 adrenergic receptor
Ligand
BDBM50272876
Substrate
n/a
Meas. Tech.
ChEMBL_514435 (CHEMBL974622)
EC50
>1000±n/a nM
Citation
Imanishi, M; Nakajima, Y; Tomishima, Y; Hamashima, H; Washizuka, K; Sakurai, M; Matsui, S; Imamura, E; Ueshima, K; Yamamoto, T; Yamamoto, N; Ishikawa, H; Nakano, K; Unami, N; Hamada, K; Matsumura, Y; Takamura, F; Hattori, K Discovery of a novel series of benzoic acid derivatives as potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. 3. Phenylethanolaminotetraline (PEAT) skeleton containing biphenyl or biphenyl ether moiety. J Med Chem 51:4804-22 (2008) [PubMed] Article
More Info.:
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
Inhibitor
Name:
BDBM50272876
Synonyms:
4-((7S)-7-{[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoic Acid | CHEMBL498302
Type:
Small organic molecule
Emp. Form.:
C25H24ClNO3
Mol. Mass.:
421.916
SMILES:
O[C@@H](CN[C@H]1CCc2ccc(cc2C1)-c1ccc(cc1)C(O)=O)c1cccc(Cl)c1 |r|