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Target
Beta-3 adrenergic receptor
Ligand
BDBM50378066
Substrate
n/a
Meas. Tech.
ChEMBL_578237 (CHEMBL1051552)
EC50
340±n/a nM
Citation
 Maruyama, T; Seki, N; Onda, K; Suzuki, T; Kawazoe, S; Hayakawa, M; Matsui, T; Takasu, T; Ohta, M Discovery of novel thiourea derivatives as potent and selective beta3-adrenergic receptor agonists. Bioorg Med Chem 17:5510-9 (2009) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50378066
Synonyms:
CHEMBL1203994
Type:
Small organic molecule
Emp. Form.:
C24H26N4O4S
Mol. Mass.:
466.553
SMILES:
O[C@@H](CNCCc1ccc(NC(=S)Nc2ccccc2[N+]([O-])=O)cc1)COc1ccccc1 |r|
Structure:
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