Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50248930
Substrate
n/a
Meas. Tech.
ChEMBL_578681 (CHEMBL1063062)
Ki
29.8±n/a nM
Citation
Zampieri, D; Mamolo, MG; Laurini, E; Florio, C; Zanette, C; Fermeglia, M; Posocco, P; Paneni, MS; Pricl, S; Vio, L Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for sigma(1) receptor ligands based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives. J Med Chem 52:5380-93 (2009) [PubMed] Article
More Info.:
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
Rat
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
Inhibitor
Name:
BDBM50248930
Synonyms:
3-((1-(2-methylbenzyl)piperidin-4-yl)methyl)benzo[d]oxazol-2(3H)-one | 3-[[1-(2-Methylbenzyl)piperidin-4-yl]methyl]benzo[d]oxazol-2(3H)-one | CHEMBL474175
Type:
Small organic molecule
Emp. Form.:
C21H24N2O2
Mol. Mass.:
336.4275
SMILES:
Cc1ccccc1CN1CCC(Cn2c3ccccc3oc2=O)CC1