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Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM25116
Substrate
n/a
Meas. Tech.
ChEMBL_587119 (CHEMBL1051329)
IC50
26±n/a nM
Citation
 Bain, J; Plater, L; Elliott, M; Shpiro, N; Hastie, CJ; McLauchlan, H; Klevernic, I; Arthur, JS; Alessi, DR; Cohen, P The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315 (2007) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
  
Inhibitor
Name:
BDBM25116
Synonyms:
1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | CHEMBL306380 | PP1 | US10688093, Compound PP1 (Pfizer) | US10807986, Comparative compound 1 | US11046696, Compound 1 of Comparative Examples | US11701353, PP1 (Pfizer) | cid_1400
Type:
Small organic molecule
Emp. Form.:
C16H19N5
Mol. Mass.:
281.3556
SMILES:
Cc1ccc(cc1)-c1nn(c2ncnc(N)c12)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: