Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM47541
Substrate
n/a
Meas. Tech.
ChEMBL_661809 (CHEMBL1252125)
IC50
1010±n/a nM
Citation
 El Turk, F; Fauvet, B; Ouertatani-Sakouhi, H; Lugari, A; Betzi, S; Roche, P; Morelli, X; Lashuel, HA An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem 18:5425-40 (2010) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM47541
Synonyms:
1-(2-chlorophenyl)-3-(2-pyridinyl)thiourea | 1-(2-chlorophenyl)-3-(2-pyridyl)thiourea | 1-(2-chlorophenyl)-3-(pyridin-2-yl)thiourea | 1-(2-chlorophenyl)-3-pyridin-2-yl-thiourea | 1-(2-chlorophenyl)-3-pyridin-2-ylthiourea | CHEMBL1253185 | MLS000665964 | N-(2-chlorophenyl)-N'-2-pyridinylthiourea | SMR000294655 | cid_972361
Type:
Small organic molecule
Emp. Form.:
C12H10ClN3S
Mol. Mass.:
263.746
SMILES:
Clc1ccccc1NC(=S)Nc1ccccn1
Structure:
Search PDB for entries with ligand similarity: