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Target
Lethal(3)malignant brain tumor-like protein 3
Ligand
BDBM50378025
Substrate
n/a
Meas. Tech.
ChEMBL_684949 (CHEMBL1286364)
IC50
85000±n/a nM
Citation
 Kireev, D; Wigle, TJ; Norris-Drouin, J; Herold, JM; Janzen, WP; Frye, SV Identification of non-peptide malignant brain tumor (MBT) repeat antagonists by virtual screening of commercially available compounds. J Med Chem 53:7625-31 (2010) [PubMed]  Article 
Target
Name:
Lethal(3)malignant brain tumor-like protein 3
Synonyms:
H-l(3)mbt-like protein 3 | KIAA1798 | L(3)mbt-like protein 3 | L3MBTL3 | LMBL3_HUMAN | Lethal(3)malignant brain tumor-like protein 3 | Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) | MBT-1 | MBT1
Type:
Protein
Mol. Mass.:
88334.17
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
780
Sequence:
MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDENEMENVKKATATTTWMVPTAQEAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKTGMPFRLKDPVKVEGLQFCENCCQYGNVDECLSGGNYCSQNCARHIKDKDQKEERDVEEDNEEEDPKCSRKKKPKLSLKADTKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSAVLKQGLPPKGKKAWCWASYLEEEKAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVCGYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQTYLKTCKAQAAPKSLFENQNITVIPSGFRVGMKLEAVDKKNPSFICVATVTDMVDNRFLVHFDNWDESYDYWCEASSPHIHPVGWCKEHRRTLITPPGYPNVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPPLSPLELMEASEHGGCSTPGCKGIGHFKRARHLGPHSAANCPYSEINLNKDRIFPDRLSGEMPPASPSFPRNKRTDANESSSSPEIRDQHADDVKEDFEERTESEMRTSHEARGAREEPTVQQAQRRSAVFLSFKSPIPCLPLRWEQQSKLLPTVAGIPASKVSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAEKNSHNEL
  
Inhibitor
Name:
BDBM50378025
Synonyms:
BA-34276 | MAPROTILINE
Type:
Small organic molecule
Emp. Form.:
C20H23N
Mol. Mass.:
277.4033
SMILES:
CNCCC[C@@]12CC[C@@H](c3ccccc13)c1ccccc21 |r,wU:8.7,5.4,TLB:10:9:20.15:6.7,16:15:14.9:6.7,THB:19:20:14.9:6.7,(13.7,-13.36,;12.37,-14.14,;11.04,-13.36,;11.07,-11.84,;9.76,-11.03,;9.77,-9.52,;10.03,-7.65,;9.58,-6.54,;9.53,-8.17,;10.87,-8.76,;11.98,-7.68,;13.44,-8.18,;13.75,-9.68,;12.6,-10.68,;11.13,-10.14,;8.07,-8.82,;6.63,-8.16,;5.41,-9.11,;5.63,-10.63,;7.06,-11.2,;8.26,-10.19,)|
Structure:
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