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Target
Sodium- and chloride-dependent glycine transporter 1
Ligand
BDBM50335025
Substrate
n/a
Meas. Tech.
ChEMBL_702705 (CHEMBL1657779)
IC50
>10000±n/a nM
Citation
 Kohara, A; Doihara, H; Saita, K; Aota, M Synthesis and biological evaluation of 3-biphenyl-4-yl-4-phenyl-4H-1,2,4-triazoles as novel glycine transporter 1 inhibitors. J Med Chem 54:387-91 (2011) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 1
Synonyms:
GlyT-1 | GlyT1 | Glycine transporter 1 | SC6A9_RAT | Slc6a9 | Sodium- and chloride-dependent glycine transporter 1 | Solute carrier family 6 member 9
Type:
Enzyme Catalytic Domain
Mol. Mass.:
71066.17
Organism:
attus norvegicus (Rat)
Description:
Glycine-1-transporter 0 HUMAN::P28572
Residue:
638
Sequence:
MAVAHGPVATSSPEQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPTALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGDFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPKWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPTIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTTTPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
  
Inhibitor
Name:
BDBM50335025
Synonyms:
3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-trifluoromethyl-4H-1,2,4-triazole | CHEMBL1649973
Type:
Small organic molecule
Emp. Form.:
C21H13F4N3
Mol. Mass.:
383.3416
SMILES:
Fc1ccccc1-n1c(nnc1C(F)(F)F)-c1ccc(cc1)-c1ccccc1 |(15.61,2.56,;14.28,1.79,;14.28,.25,;12.94,-.52,;11.61,.25,;11.61,1.79,;12.95,2.56,;12.95,4.09,;11.7,4.99,;12.18,6.46,;13.72,6.46,;14.2,4.99,;15.73,4.99,;16.51,3.66,;16.5,6.33,;17.27,4.99,;10.38,4.22,;10.39,2.67,;9.06,1.9,;7.72,2.67,;7.71,4.2,;9.04,4.98,;6.39,1.9,;5.06,2.66,;3.73,1.89,;3.73,.35,;5.06,-.43,;6.4,.35,)|
Structure:
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