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Target
Kappa-type opioid receptor
Ligand
BDBM50347176
Substrate
n/a
Meas. Tech.
ChEMBL_753738 (CHEMBL1799575)
Ki
21.7±n/a nM
Citation
 Yamamoto, N; Fujii, H; Nemoto, T; Nakajima, R; Momen, S; Izumimoto, N; Hasebe, K; Mochizuki, H; Nagase, H Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1. Bioorg Med Chem Lett 21:4104-7 (2011) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50347176
Synonyms:
CHEMBL1797686
Type:
Small organic molecule
Emp. Form.:
C20H25NO3
Mol. Mass.:
327.4174
SMILES:
Oc1ccc2CC34CCC(=O)CC3(CCN(CC3(O)CC3)C4)c2c1
Structure:
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