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Target
D(2) dopamine receptor
Ligand
BDBM50382304
Substrate
n/a
Meas. Tech.
ChEMBL_816864 (CHEMBL2026135)
IC50
29±n/a nM
Citation
 Agai-Csongor, E; Domány, G; Nógrádi, K; Galambos, J; Vágó, I; Keseru, GM; Greiner, I; Laszlovszky, I; Gere, A; Schmidt, E; Kiss, B; Vastag, M; Tihanyi, K; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Kapás, M; Szombathelyi, Z Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg Med Chem Lett 22:3437-40 (2012) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50382304
Synonyms:
CHEMBL2024520
Type:
Small organic molecule
Emp. Form.:
C19H28Cl2N4O
Mol. Mass.:
399.358
SMILES:
NC(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccc(Cl)c(Cl)c2)CC1 |r,wU:4.3,wD:7.7,(-1.68,-12.4,;-.35,-11.63,;-.35,-10.09,;.99,-12.4,;2.32,-11.63,;2.32,-10.09,;3.65,-9.31,;4.98,-10.09,;6.31,-9.32,;7.64,-10.1,;8.98,-9.33,;10.3,-10.11,;11.64,-9.35,;11.65,-7.81,;10.32,-7.03,;8.97,-7.79,;12.99,-7.05,;14.33,-7.82,;15.66,-7.05,;15.66,-5.52,;17,-4.76,;14.33,-4.74,;14.34,-3.2,;12.99,-5.51,;4.98,-11.63,;3.65,-12.39,)|
Structure:
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