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Target
Dual specificity protein phosphatase 6
Ligand
BDBM26613
Substrate
n/a
Meas. Tech.
ChEMBL_829769 (CHEMBL2061288)
IC50
>10000±n/a nM
Citation
 Mak, LH; Knott, J; Scott, KA; Scott, C; Whyte, GF; Ye, Y; Mann, DJ; Ces, O; Stivers, J; Woscholski, R Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases. Bioorg Med Chem 20:4371-6 (2012) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_HUMAN | DUSP6 | Dual specificity protein phosphatase PYST1 | MAP kinase phosphatase 3 | MKP3 | Mitogen-activated protein kinase phosphatase 3 | PYST1
Type:
PROTEIN
Mol. Mass.:
42305.16
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476409
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTTPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM26613
Synonyms:
(2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-enoic acid | Compound 13778
Type:
Small organic molecule
Emp. Form.:
C9H9O5Sb
Mol. Mass.:
318.92
SMILES:
OC(=O)\C=C\c1cccc(c1)[Sb](O)(O)=O
Structure:
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