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Target
Max-like protein X
Ligand
BDBM50388968
Substrate
n/a
Meas. Tech.
ChEMBL_833604 (CHEMBL2066545)
Ki
70±n/a nM
Citation
 Flygare, JA; Beresini, M; Budha, N; Chan, H; Chan, IT; Cheeti, S; Cohen, F; Deshayes, K; Doerner, K; Eckhardt, SG; Elliott, LO; Feng, B; Franklin, MC; Reisner, SF; Gazzard, L; Halladay, J; Hymowitz, SG; La, H; LoRusso, P; Maurer, B; Murray, L; Plise, E; Quan, C; Stephan, JP; Young, SG; Tom, J; Tsui, V; Um, J; Varfolomeev, E; Vucic, D; Wagner, AJ; Wallweber, HJ; Wang, L; Ware, J; Wen, Z; Wong, H; Wong, JM; Wong, M; Wong, S; Yu, R; Zobel, K; Fairbrother, WJ Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem 55:4101-13 (2012) [PubMed]  Article 
Target
Name:
Max-like protein X
Synonyms:
BHLHD13 | Class D basic helix-loop-helix protein 13 | MLX | MLX_HUMAN | Max-like bHLHZip protein | Protein BigMax | TCFL4 | Transcription factor-like protein 4
Type:
PROTEIN
Mol. Mass.:
33306.36
Organism:
Human
Description:
ChEMBL_833604
Residue:
298
Sequence:
MTEPGASPEDPWVKASPVGAHAGEGRAGRARARRGAGRRGASLLSPKSPTLSVPRGCREDSSHPACAKVEYAYSDNSLDPGLFVESTRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY
  
Inhibitor
Name:
BDBM50388968
Synonyms:
CHEMBL2063866
Type:
Small organic molecule
Emp. Form.:
C31H42N4O3
Mol. Mass.:
518.6902
SMILES:
CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NCC(c1ccccc1)c1ccccc1 |r|
Structure:
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