Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391393
Substrate
n/a
Meas. Tech.
ChEMBL_848925 (CHEMBL2149719)
Ki
1.5±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rat
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391393
Synonyms:
CHEMBL2146504
Type:
Small organic molecule
Emp. Form.:
C28H38N4O2S2
Mol. Mass.:
526.757
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:26.28,6.5,(-3.08,-4.55,;-3.07,-3.01,;-4.4,-2.23,;-4.38,-.69,;-3.04,.07,;-1.72,-.71,;-.38,.05,;.95,-.75,;2.28,.01,;2.31,1.55,;.98,2.33,;-.37,1.58,;3.65,2.3,;4.97,1.52,;5.73,.19,;4.2,.19,;6.32,2.27,;6.33,3.8,;7.68,4.55,;9.01,3.76,;10.35,4.5,;11.67,3.72,;11.65,2.17,;10.3,1.42,;8.98,2.21,;7.63,1.47,;-5.65,.19,;-5.18,1.66,;-6.22,2.79,;-7.71,2.46,;-8.97,3.36,;-10.2,2.44,;-11.67,2.91,;-9.72,.98,;-8.17,.99,;-7.14,-.13,)|
Structure:
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