Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50395586
Substrate
n/a
Meas. Tech.
ChEMBL_859682 (CHEMBL2169117)
Ki
145±n/a nM
Citation
 Chen, X; Sassano, MF; Zheng, L; Setola, V; Chen, M; Bai, X; Frye, SV; Wetsel, WC; Roth, BL; Jin, J Structure-functional selectivity relationship studies ofß-arrestin-biased dopamine D2 receptor agonists. J Med Chem 55:7141-53 (2012) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50395586
Synonyms:
CHEMBL2165128
Type:
Small organic molecule
Emp. Form.:
C27H33Cl2N3O2
Mol. Mass.:
502.476
SMILES:
Clc1cccc(N2CCN(C[C@H]3CC[C@H](COc4ccc5CCC(=O)Nc5c4)CC3)CC2)c1Cl |r,wU:11.10,wD:14.14,(.73,-4.74,;.75,-6.28,;-.59,-7.06,;-.55,-8.61,;.79,-9.36,;2.11,-8.57,;3.45,-9.32,;3.47,-10.85,;4.81,-11.61,;6.13,-10.82,;7.46,-11.58,;8.79,-10.79,;8.77,-9.25,;10.1,-8.47,;11.45,-9.22,;12.77,-8.44,;12.76,-6.9,;14.07,-6.1,;15.42,-6.85,;16.74,-6.05,;16.7,-4.52,;18.03,-3.72,;18,-2.18,;16.64,-1.42,;16.6,.12,;15.3,-2.23,;15.34,-3.77,;14.03,-4.57,;11.46,-10.76,;10.14,-11.54,;6.12,-9.28,;4.78,-8.54,;2.09,-7.03,;3.42,-6.24,)|
Structure:
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