Reaction Details Report a problem with these data
Target
Sodium/hydrogen exchanger 1
Ligand
BDBM50396467
Substrate
n/a
Meas. Tech.
ChEMBL_862405 (CHEMBL2173435)
IC50
29±n/a nM
Citation
Huber, JD; Bentzien, J; Boyer, SJ; Burke, J; De Lombaert, S; Eickmeier, C; Guo, X; Haist, JV; Hickey, ER; Kaplita, P; Karmazyn, M; Kemper, R; Kennedy, CA; Kirrane, T; Madwed, JB; Mainolfi, E; Nagaraja, N; Soleymanzadeh, F; Swinamer, A; Eldrup, AB Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. J Med Chem 55:7114-40 (2012) [PubMed] Article
More Info.:
Target
Name:
Sodium/hydrogen exchanger 1
Synonyms:
APNH | APNH1 | NHE-1 | NHE1 | Na(+)/H(+) antiporter, amiloride-sensitive | Na(+)/H(+) exchanger 1 | SL9A1_HUMAN | SLC9A1 | Solute carrier family 9 member 1
Type:
PROTEIN
Mol. Mass.:
90771.96
Organism:
Human
Description:
ChEMBL_862405
Residue:
815
Sequence:
MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTPAPSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ