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Target
Cannabinoid receptor 1
Ligand
BDBM50397395
Substrate
n/a
Meas. Tech.
ChEMBL_864943 (CHEMBL2175893)
Ki
562±n/a nM
Citation
 El Bakali, J; Gilleron, P; Body-Malapel, M; Mansouri, R; Muccioli, GG; Djouina, M; Barczyk, A; Klupsch, F; Andrzejak, V; Lipka, E; Furman, C; Lambert, DM; Chavatte, P; Desreumaux, P; Millet, R 4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis. J Med Chem 55:8948-52 (2012) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50397395
Synonyms:
CHEMBL2170549
Type:
Small organic molecule
Emp. Form.:
C25H38N2O2
Mol. Mass.:
398.5814
SMILES:
CCCCCn1cc(C(=O)NC2C3CC4CC(C3)CC2C4)c(=O)cc1C(C)(C)C |TLB:20:19:17:13.14.15,THB:10:11:17:13.14.15,20:14:11.19.18:17,15:14:11:18.16.17,15:16:11:13.20.14,(4.03,-16.9,;5.37,-17.68,;6.72,-16.91,;8.05,-17.69,;9.39,-16.91,;10.72,-17.69,;12.07,-16.92,;13.41,-17.7,;14.74,-16.93,;14.75,-15.38,;16.08,-17.71,;17.52,-16.99,;18.67,-15.86,;19.88,-16.36,;21.18,-16.1,;21.25,-14.69,;19.98,-14.1,;18.72,-14.49,;18.98,-15.2,;18.92,-16.66,;20.19,-17.24,;13.4,-19.24,;14.74,-20.02,;12.06,-20.01,;10.72,-19.24,;9.38,-20,;9.38,-21.54,;8.05,-19.23,;8.04,-20.77,)|
Structure:
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