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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50229962
Substrate
n/a
Meas. Tech.
ChEMBL_874333 (CHEMBL2182241)
IC50
104±n/a nM
Citation
 Berg, S; Bergh, M; Hellberg, S; Högdin, K; Lo-Alfredsson, Y; Söderman, P; von Berg, S; Weigelt, T; Ormö, M; Xue, Y; Tucker, J; Neelissen, J; Jerning, E; Nilsson, Y; Bhat, R Discovery of novel potent and highly selective glycogen synthase kinase-3ß (GSK3ß) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines. J Med Chem 55:9107-19 (2012) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Human
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50229962
Synonyms:
1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | AR-A014418 | CHEMBL259850 | N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA
Type:
Small organic molecule
Emp. Form.:
C12H12N4O4S
Mol. Mass.:
308.313
SMILES:
COc1ccc(CNC(=O)Nc2ncc(s2)[N+]([O-])=O)cc1
Structure:
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