Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM50399055
Substrate
n/a
Meas. Tech.
ChEMBL_878773 (CHEMBL2183713)
Ki
11300±n/a nM
Citation
 Dahlgren, MK; Garcia, AB; Hare, AA; Tirado-Rives, J; Leng, L; Bucala, R; Jorgensen, WL Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor. J Med Chem 55:10148-59 (2012) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
Macrophage migration inhibitory factor (MIF)
Type:
Enzyme
Mol. Mass.:
12844.38
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
Q6Q3H7
Residue:
116
Sequence:
MPCCEVITNVNLPDDNVQSTLSQIENAISDVMGKPLGYIMSNYDYQKNLRFGGSNEAYCFVRITSIGGINRSNNSALADQITKLLVSNLNVKSRRIYVEFRDCSAQNFAFSGSLFG
  
Inhibitor
Name:
BDBM50399055
Synonyms:
CHEMBL2178850
Type:
Small organic molecule
Emp. Form.:
C17H17N3O2
Mol. Mass.:
295.3358
SMILES:
Cc1cc(Oc2cccc(c2)C#N)cc(n1)N1CCOCC1
Structure:
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