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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50307935
Substrate
n/a
Meas. Tech.
ChEMBL_887649 (CHEMBL2217258)
IC50
>27000±n/a nM
Citation
 Barf, T; Kaptein, A Irreversible protein kinase inhibitors: balancing the benefits and risks. J Med Chem 55:6243-62 (2012) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Proto-oncogene c-Src | SRC | SRC_CHICK | Tyrosine-protein kinase SRC | c-Src | p60-Src | p60c-src | pp60c-src
Type:
Tyr protein kinase
Mol. Mass.:
60015.36
Organism:
Gallus gallus (Chicken)
Description:
P00523
Residue:
533
Sequence:
MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKLFGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50307935
Synonyms:
(2R,3S)-N-(4-(3-Bromoanilino)quinazolin-6-yl)-3-(piperidin-1-ylmethyl)oxirane-2-carboxamide | CHEMBL598007
Type:
Small organic molecule
Emp. Form.:
C23H24BrN5O2
Mol. Mass.:
482.373
SMILES:
Brc1cccc(Nc2ncnc3ccc(NC(=O)[C@@H]4O[C@H]4CN4CCCCC4)cc23)c1 |r|
Structure:
Search PDB for entries with ligand similarity: