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Target
Prothrombin
Ligand
BDBM50404619
Substrate
n/a
Meas. Tech.
ChEMBL_210578 (CHEMBL816529)
IC50
500000±n/a nM
Citation
 Kikumoto, R; Tamao, Y; Ohkubo, K; Tezuka, T; Tonomura, S; Okamoto, S; Funahara, Y; Hijikata, A Thrombin inhibitors. 2. Amide derivatives of N alpha-substituted L-arginine. J Med Chem 23:830-6 (1980) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | THRB_BOVIN | Thrombin | Thrombin heavy chain | Thrombin light chain
Type:
Enzyme
Mol. Mass.:
70502.73
Organism:
Bos taurus (Bovine)
Description:
P00735
Residue:
625
Sequence:
MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS
  
Inhibitor
Name:
BDBM50404619
Synonyms:
CHEMBL352546
Type:
Small organic molecule
Emp. Form.:
C26H34N6O4S
Mol. Mass.:
526.651
SMILES:
COc1ccc(CNC(=O)C(CCCNC(N)=N)NS(=O)(=O)c2cccc3c(cccc23)N(C)C)cc1
Structure:
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