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Target
Reverse transcriptase/RNaseH
Ligand
BDBM2239
Substrate
n/a
Meas. Tech.
ChEMBL_195671 (CHEMBL800744)
IC50
37±n/a nM
Citation
 Hoffman, JM; Smith, AM; Rooney, CS; Fisher, TE; Wai, JS; Thomas, CM; Bamberger, DL; Barnes, JL; Williams, TM; Jones, JH Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogues. J Med Chem 36:953-66 (1993) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus type 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM2239
Synonyms:
2-Pyridinone derivative 19 | 3-[2-(7-Fluorobenzoxazol-2-y1)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one | 5-ethyl-3-[2-(7-fluoro-1,3-benzoxazol-2-yl)ethyl]-6-methyl-1,2-dihydropyridin-2-one | CHEMBL367052
Type:
Small organic molecule
Emp. Form.:
C17H17FN2O2
Mol. Mass.:
300.3275
SMILES:
CCc1cc(CCc2nc3cccc(F)c3o2)c(=O)[nH]c1C
Structure:
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