Reaction Details Report a problem with these data
Target
Inosine-5'-monophosphate dehydrogenase
Ligand
BDBM50426039
Substrate
n/a
Meas. Tech.
ChEMBL_934903 (CHEMBL2319789)
IC50
52±n/a nM
Citation
 Johnson, CR; Gorla, SK; Kavitha, M; Zhang, M; Liu, X; Striepen, B; Mead, JR; Cuny, GD; Hedstrom, L Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. Bioorg Med Chem Lett 23:1004-7 (2013) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase
Synonyms:
Cgd6_20 protein | IMDH_CRYPV | Inosine-5'-monophosphate dehydrogenase, probable | Inosine-5-monophosphate dehydrogenase (IMPDH)
Type:
Protein
Mol. Mass.:
43076.80
Organism:
Cryptosporidium parvum
Description:
Q8T6T2
Residue:
400
Sequence:
MGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNNIDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYRGMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
  
Inhibitor
Name:
BDBM50426039
Synonyms:
CHEMBL2315258
Type:
Small organic molecule
Emp. Form.:
C19H13F3N4O2
Mol. Mass.:
386.3273
SMILES:
Cn1nc(CC(=O)Nc2ccc(C#N)c(c2)C(F)(F)F)c2ccccc2c1=O
Structure:
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