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Target
Sodium- and chloride-dependent betaine transporter
Ligand
BDBM50020883
Substrate
n/a
Meas. Tech.
ChEMBL_941200 (CHEMBL2329711)
IC50
>1000000±n/a nM
Citation
 Vogensen, SB; Jørgensen, L; Madsen, KK; Borkar, N; Wellendorph, P; Skovgaard-Petersen, J; Schousboe, A; White, HS; Krogsgaard-Larsen, P; Clausen, RP Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization. J Med Chem 56:2160-4 (2013) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent betaine transporter
Synonyms:
GABA transporter | GABA transporter 2 | Gabt2 | Gat-2 | Gat2 | S6A12_MOUSE | Slc6a12
Type:
PROTEIN
Mol. Mass.:
69615.88
Organism:
Mus musculus
Description:
ChEMBL_1460088
Residue:
614
Sequence:
MDRKVAVHEDGYPVVSWVPEEGEMMDQKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNHSSARGVSSSENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMSQEQGIPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLLFLGLDSQFVCMECLVTASMDMFPQQLRKSGRRDVLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYMYPSWGYSIGWLLAFSSMACVPLFIIITFLKTQGSFKKRLRRLITPDPSLPQPGRRPPQDGSSAQNCSSSPAKQELIAWEKETHL
  
Inhibitor
Name:
BDBM50020883
Synonyms:
(R)-Piperidine-3-carboxylic acid | (R)-nipecotic acid | CHEMBL77575 | Nipecotic acid
Type:
Small organic molecule
Emp. Form.:
C6H11NO2
Mol. Mass.:
129.157
SMILES:
OC(=O)[C@@H]1CCCNC1 |r|
Structure:
Search PDB for entries with ligand similarity: