Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50429069
Substrate
n/a
Meas. Tech.
ChEMBL_943180 (CHEMBL2346211)
Ki
2.0±n/a nM
Citation
 Giovanni, A; Roehr, J; Dwyer, S; Neuenschwander, K; Scotese, A; Moorcroft, ND; Davis, L; Gao, Z Design and synthesis of D1 agonist/D2 antagonist for treatment of schizophrenia. Bioorg Med Chem Lett 23:1498-501 (2013) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Human
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50429069
Synonyms:
CHEMBL2335736
Type:
Small organic molecule
Emp. Form.:
C21H22F3NO4
Mol. Mass.:
409.3989
SMILES:
COc1cc2CCN3CC[C@@](O)(C[C@@H]3c2cc1O)c1ccc(OC(F)(F)F)cc1 |r|
Structure:
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